Depends on the time of day. If at all possible, try to time it to avoid rush hour (roughly 4:00 to 7:00PM weekdays). If you can do that, Woodall Rogers across the north edge of downtown is as good as any and would be my choice (even though it sounds like you want to avoid it). Alternatively, continue north on I35 and take 635 across.
If you can't avoid rush hour then your best bets are I20 across to I45 and then north, or take I35E all the way through to George Bush Tollway and across to 75. There's really no good option at rush hour, though, it's pretty much a tossup.
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