It really depends:
the Las Vegas valley is getting more and more difficult to get around (the traffic here isn't that bad compared to larger cities with SoCal being the closest example but it can be bad at times). You really need a reliable car to get around. The alternatives tend to be trying to get a cab (depending on where you live in the valley, that may be a long wait) or using the CAT public transit system which isn't ideal for good looking, well dressed lady. While I'm a guy and have few issues walking through most of the valley, I'm not sure how an attractive lady would feel walking on her own, esp at night. Walking along the strip area or the downtown area (mostly near Fremont Street Experience or just east of there to roughly the El Cortez) is fairly touristy and safe (except from other drunk people trying to grabass).
Las Vegas is a popular convention destination and with all the gambling, world class restaurants, and popular nightclubs, attracts people that will spend money. Most of the visitors are gravitating towards the strip corridor, don't usually rent cars, and have a room that they'd prefer to get outcall service to. As a Las Vegas based provider, this type of client is where you will find a vast majority of your appointments. A regular may come during a particular trade show (anywhere from twice a year to once every 3 years for the larger ones that are held here on a regular basis) and/or make the occasional personal trip out here (with SoCal being the largest drive-in market).
As a local, we're either OK with providers coming to our homes or going to an incall location. My own preference is incall and I do make the occasional hotel booking to see those that are outcall only. Unless you want to cater to locals, an incall is not a must have in Vegas. A reliable ride is much more important. Some providers will book a room for incalls and pass on the cost of the room to the clients, or advertise a special to make the best use of a temporary incall. I know of a guy that comes in from out of town on a regular basis and one of the first things he does is calls housekeeping for bunch of extra towels (tips around $5-10). Probably a great idea if you're going to be using a hotel room for incall for more than 1 appointment. With that said, I'm fairly certain that we're in the minority of clients in Vegas compared to visitors wanting outcalls to their room. With the local economy doing worse than the rest of the nation, I'd say this is even more skewed to the monied visitor.
So, assuming you have a vehicle, where should you live. For a somewhat suburban elitist type of area, I usually point to Summerlin and Green Valley. Summerlin is directly west of downtown Las Vegas (
http://www.summerlin.com/map/), at least the more established parts of it. Green Valley is in western part of Henderson (map of GVR area:
http://www.greenvalleyranchmarketrep...v-master-plan/) and if you look at that map, encompasses an area there and nearby. Depending on how often you need to fly in and out of Vegas, Green Valley is closer and easier to get to McCarran than Summerlin. Outside of those two, there are plenty of neighborhoods that probably fit your style and comfort level.
Hope that gives you a little flavor of what to expect.
Bob