Both are English friendly. Actually, depending on who you’re talking to, it’s easier to speak English than Spanish due to different dialects.
Nonetheless. it doesn’t hurt to know some Spanish. Learn your coordinates and basic questions and you’ll be fine.
Personally, I prefer Cartegena as it is more touristy and welcoming to Americans. On the other hand, doing a trip from Cartegena to Bogota would be well worth it.
Which, if you do a bus from Cartegena to Bogota, please do some extensive research! The more informed you are, the better.
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